Involvement of the Bcl‐2 Family Members in Pinus massoniana Bark Extract induced Apoptosis in HeLa Cells
H Ma, F Lai, H Xie, J Wang… - … Research: An International …, 2008 - Wiley Online Library
Pinus massoniana bark extract (PMBE) contains a variety of flavonoids whose antioxidant
properties have been confirmed in vitro. This study was undertaken to evaluate the cytotoxic
effects and the mechanism of cell death on the PMBE‐treated human cervical cancer cell
line, HeLa. PMBE treatment led to cell growth inhibition in a dose‐and time‐dependent
manner, and PMBE‐induced apoptosis was confirmed by DAPI staining, TUNEL assays and
sub‐G1 phase accumulation. Cell cycle was also arrested in G2/M phase. Immunoblotting …
properties have been confirmed in vitro. This study was undertaken to evaluate the cytotoxic
effects and the mechanism of cell death on the PMBE‐treated human cervical cancer cell
line, HeLa. PMBE treatment led to cell growth inhibition in a dose‐and time‐dependent
manner, and PMBE‐induced apoptosis was confirmed by DAPI staining, TUNEL assays and
sub‐G1 phase accumulation. Cell cycle was also arrested in G2/M phase. Immunoblotting …
Involvement of the Bcl-2 family members in Pinus massoniana bark extract induced apoptosis in HeLa cells.
MHL Ma HongLing, LF Lai Fei, XH Xie Heng… - 2008 - cabidigitallibrary.org
Pinus massoniana bark extract (PMBE) contains a variety of flavonoids whose antioxidant
properties have been confirmed in vitro. This study was undertaken to evaluate the cytotoxic
effects and the mechanism of cell death on the PMBE-treated human cervical cancer cell
line, HeLa. PMBE treatment led to cell growth inhibition in a dose-and time-dependent
manner, and PMBE-induced apoptosis was confirmed by DAPI staining, TUNEL assays and
sub-G1 phase accumulation. Cell cycle was also arrested in G2/M phase. Immunoblotting …
properties have been confirmed in vitro. This study was undertaken to evaluate the cytotoxic
effects and the mechanism of cell death on the PMBE-treated human cervical cancer cell
line, HeLa. PMBE treatment led to cell growth inhibition in a dose-and time-dependent
manner, and PMBE-induced apoptosis was confirmed by DAPI staining, TUNEL assays and
sub-G1 phase accumulation. Cell cycle was also arrested in G2/M phase. Immunoblotting …
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